,Priming the seed: Helicobacter pylori alters epithelial cell invasiveness in early gastric carcinogenesis

S., Molina-Castro; V., Ramírez-Mayorga; W., Alpizar-Alpizar

Abstract:

Helicobacter pylori (H. pylori) infection is a well-established risk factor for the development of gastric cancer (GC), one of the most common and deadliest neoplasms worldwide. H. pylori infection induces chronic inflammation in the gastric mucosa that, in the absence of treatment, may progress through a series of steps to GC. GC is only one of several clinical outcomes associated with this bacterial infection, which may be at least partially attributed to the high genetic variability of H. pylori. The biological mechanisms underlying how and under what circumstances H. pylori alters normal physiological processes remain enigmatic. A key aspect of carcinogenesis is the acquisition of traits that equip preneoplastic cells with the ability to invade. Accumulating evidence implicates H. pylori in the manipulation of cellular and molecular programs that are crucial for conferring cells with invasive capabilities. We present here an overview of the main findings about the involvement of H. pylori in the acquisition of cell invasive behavior, specifically focusing on the epithelial-to-mesenchymal transition, changes in cell polarity, and deregulation of molecules that control extracellular matrix remodeling. Molina-Castro S, Ramírez-Mayorga V, Alpízar-Alpízar W. Priming the seed: Helicobacter pylori alters epithelial cell invasiveness in early gastric carcinogenesis. World J Gastrointest Oncol 2018; 10(9): 231-243 [PMID: 30254719 DOI: 10.4251/wjgo.v10.i9.231]

Año:

2018

Tipo de publicación:

Artículo

Journal:

Word journal of gastrointestinal Oncology

Volumen:

10

Número:

9

Páginas:

231-243

DOI:

10.4251/wjgo.v10.i9.231