Molina Castro Silvia, Dra.
Programa de Epidemiología del Cáncer, INISA
Correo electrónico: This email address is being protected from spambots. You need JavaScript enabled to view it.
Teléfonos: (506) 2511-2150 / (506) 2511-3376
ORCID: https://orcid.org/0000-0002-7523-9919
Estudios universitarios
Licenciatura en Microbiología y Química Clínica. UCR
Especialidad en Inmunología Clínica. UCR
Maestría Académica en Microbiología. UCR
Doctorado Académico en Microbiología e Inmunología. Universidad de Bordeaux
Intereses de Investigación
Carcinogénesis gastrointestinal: infección con Helicobacter pylori, células madre cancerosas, respuesta inmune en mucosas gastrointestinales, prevención de lesiones precancerosas.
Mecanismos de interacción-hospedero patógeno e inducción de procesos inflamatorios.
Colaboraciones o vínculos con otras instituciones a nivel nacional e internacional
Unidad Académica o Programa de Posgrado de la UCR donde realiza docencia
Escuela de Medicina
Programa de Especialidades en Microbiología
Programa de Posgrado en Ciencias Biomédicas
Programa de Posgrado en Microbiología, Parasitología, Química Clínica e Inmunología
Publicaciones (últimas 10) ó Publicaciones representativas
Arias-Arias JL, Molina-Castro SE, Monturiol-Gross L, Lomonte B, Corrales-Aguilar E. Stable production of recombinant SARS-CoV-2 receptor-binding domain in mammalian cells with co-expression of a fluorescent reporter and its validation as antigenic target for COVID-19 serology testing. Biotechnol Rep (Amst). 2023 Mar; 37: e00780. Available from: https://doi.org/10.1016/j.btre.2022.e00780
Malespín-Bendaña W, Alpízar-Alpízar W, Figueroa-Protti L, Reyes L, Molina-Castro S, Une C, Ramírez-Mayorga V. Helicobacter pylori infection induces gastric precancerous lesions and persistent expression of Angpt2, Vegf-A and Tnf-A in a mouse model. Front Oncol. [Internet]. 2023 Feb; 13:1072802. Available from: https://doi.org/10.3389/fonc.2023.1072802
Molina-Castro S, Campos-Núñez C, Durán-Bermúdez S, Chaves-Cervantes M, Ramírez-Mayorga V. Cultivo primario de Helicobacter pylori a partir de biopsias gástricas obtenidas por endoscopia. Acta méd. Costarric. [Internet]. 2022 Jun; 64(2):24-32. Available from: https://doi.org/10.51481/amc.v64i2.1180
Molina-Castro G, Matarrita-Muñoz S, Molina-Castro SE, Méndez-Chacón E, Clas U, Ramírez-Mayorga V. Exploratory multigroup structural equation modeling approach to analyzing H. pylori infection, serological pepsinogen levels, and life style factors in an elderly population in Costa Rica. PSM [Internet]. 2022 Jun; 19(2): 573-597. Available from: https://doi.org/10.15517/psm.v0i19.48113.
Malespín-Bendaña W, Machado JC, Une C, Alpízar-Alpízar W, Molina-Castro S, Ramírez-Mayorga V. The TNF-A–857*T polymorphism is associated with gastric adenocarcinoma risk in a Costa rican population. Am J Med Sci [Internet]. 2021 Aug; 362(2):182–7. Available from: https://doi.org/10.1016/j.amjms.2021.01.01
Retana Moreira L, Zamora Rojas L, Grijalba Murillo M, Molina Castro SE, Abrahams Sandí E. Primary amebic meningoencephalitis related to groundwater in Costa Rica: Diagnostic confirmation of three cases and environmental investigation. Pathogens [Internet]. 2020 Aug; 9(8):629. Available from: https://doi.org/10.3390/pathogens9080629
Tiffon C, Giraud J, Molina-Castro SE, Peru S, Seeneevassen L, Sifré E, et al. TAZ controls Helicobacter pylori-induced epithelial–mesenchymal transition and cancer stem cell-like invasive and tumorigenic properties. Cells [Internet]. 2020 Jun; 9(6):1462. Available from: https://doi.org/10.3390/cells9061462
Seeneevassen L, Giraud J, Molina-Castro S, Sifré E, Tiffon C, Beauvoit C, et al. Leukaemia inhibitory factor (LIF) inhibits cancer stem cells tumorigenic properties through Hippo kinases activation in gastric cancer. Cancers (Basel) [Internet]. 2020 Aug; 12(8):2011. Available from: https://doi.org/10.3390/cancers12082011
Molina-Castro SE, Tiffon C, Giraud J, Boeuf H, Sifre E, Giese A, et al. The hippo kinase LATS2 controls Helicobacter pylori-induced epithelial-mesenchymal transition and intestinal metaplasia in gastric mucosa. Cell Mol Gastroenterol Hepatol [Internet]. 2020 Jan; 9(2):257–76. Available from: https://doi.org/10.1016/j.jcmgh.2019.10.007
Giraud J, Molina-Castro S, Seeneevassen L, Sifré E, Izotte J, Tiffon C, et al. Verteporfin targeting YAP1/TAZ‐TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells. Int J Cancer [Internet]. 2020 Apr; 146(8):2255–67. Available from: https://doi.org/10.1002/ijc.32667